DIM and menĭIM is also of value in the management of issues related to the prostate gland and their associated lower urinary tract symptoms.Īlthough the focus is often on testosterone when it comes to men’s health, estrogen levels are also important to monitor. ,, By directly binding to dopamine receptors, furthermore, chaste berry also helps lower prolactin levels,, , which in turn can help mitigate breast pain, irregular menstrual cycles, and infertility. By supporting LH production, chaste berry helps shift the ratio of estrogen to progesterone in the body in favor of progesterone, thus further supporting fertility as well. Chaste berry acts on the hypothalamic-pituitary-ovarian axis, increasing the production of luteinizing hormone (LH), a hormone produced by the brain to trigger ovulation.Ĭhaste berry acts on the hypothalamic-pituitary-ovarian axis, increasing the production of luteinizing hormone (LH), a hormone produced by the brain to trigger ovulation. DIM in particular supports this aim when synergized with the herb chaste berry ( Vitex agnus-castus), or vitex, as it’s also commonly known. īalancing estrogen types and levels is beneficial in alleviating the symptoms of benign breast ailments (such as fibrocystic breast disease) and premenstrual syndrome (PMS). , It is important to note, however, that DIM supplements should not be used by pregnant women. By these actions, DIM may help reduce the risk of certain hormone-sensitive cancers. , DIM also has anti-estrogenic activity, competing with estrogen for binding sites on cells and reducing proliferation. DIM’s primary virtue with regard to women’s health comes from its role in helping the body to make a better balance of the “good estrogen” (2-hydroxy-estrone) compared to the “bad estrogen” (16-alpha-hydroxy-estrone). There are different estrogen metabolites in the body, some of which are more estrogenic and potentially harmful, while others are likely more protective. ,, DIM also supports healthy hormone metabolism and detoxification, and thus can be helpful in alleviating a number of hormonal-related issues in both men and women. Consumption of cruciferous vegetables is associated with a reduction of inflammation,, decreased risk of cardiovascular disease,, and even lower risks of certain types of cancer. The healing power of Brassica vegetables like broccoli, cauliflower, Brussels sprouts, cabbage, and kale comes in large part from the phytochemical indole-3-carbinol (I3C), which naturally breaks down in the gut to a constituent known as 3,3′-diindolylmethane (DIM) (pronounced “dim”). We conclude that BR-DIM is well tolerated at single doses of up to 200 mg, and that increasing the dose to 300 mg did not result in an increase in C(max).Supporting female AND male hormonal health with 3,3′-diindolylmethane The single 300-mg dose of BR-DIM resulted in a mean C(max) of 108 ng/mL and a mean AUC of 532 h ng/mL. The single 100-mg dose of BR-DIM resulted in a mean maximum plasma concentration (C(max)) of 32 ng/mL and a mean area under the curve (AUC) of 128 h ng/mL, and a single 200-mg dose produced a mean C(max) of 104 ng/mL and a mean AUC of 553 h ng/mL. Analysis of serial plasma samples showed that only one subject at the 50-mg dose had detectable concentrations of DIM. Only the latter effect was judged as probably related to the study agent. At the 300-mg dose, one of six subjects reported mild nausea and headache and one also reported vomiting. No BR-DIM-related adverse effects were reported at doses up to 200 mg. The doses administered were 50, 100, 150, 200, and 300 mg, with the 300-mg dose repeated in an additional group. After randomization, one subject in each group received placebo whereas three received active BR-DIM. Groups of four subjects were enrolled for each dose level. We determined the safety, tolerability, and pharmacokinetics of single doses of BR-DIM in drug-free, non-smoking, healthy men and women. The study agent was nutritional-grade, absorption-enhanced BioResponse 3,3'-diindolylmethane (BR-DIM). We have completed a single ascending dose clinical study of the proposed chemopreventive agent 3,3'-diindolylmethane (DIM).
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